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Depression

The Benefits of Exercise for Managing Anxiety and Depression

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Medically Reviewed by Mark Hrymoc, M.D., Chief Medical Officer, double-board certified in General & Addiction Psychiatry Exercise is one of the most effective nonpharmacologic treatments for anxiety and depression, offering a broad range of psychological and biological benefits. While often discussed in the context of physical health, regular movement directly supports the brain’s ability to regulate mood, process emotions, and build resilience. For individuals living with anxiety or depression, incorporating consistent exercise can help reduce symptom severity, improve sleep, enhance self-esteem, and support long-term recovery. The Science Behind Exercise and Mood Exercise influences multiple biological systems that govern emotional health. Physical activity stimulates the release of endorphins—natural chemicals that produce feelings of pleasure and reduce the perception of pain. It also increases serotonin, dopamine, and norepinephrine, neurotransmitters that regulate motivation, concentration, and mood. These chemical shifts can create a sense of calm and well-being, often referred to as the “exercise …

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What NRX-100 and NRX-101 Could Mean for Suicide-Focused Depression Carement

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Medically Reviewed by Mark Hrymoc, M.D., Chief Medical Officer, double-board certified in General & Addiction Psychiatry Suicidal ideation in major depressive disorder and bipolar depression remains a public health emergency, with U.S. deaths by suicide reaching historically high levels in recent years. Against this backdrop, NRx Pharmaceuticals has advanced two investigational agents that target this gap: NRX-100, a preservative-free intravenous ketamine, and NRX-101, an oral fixed-dose combination of D-cycloserine and lurasidone. Understanding how FDA pathways such as Fast Track and Accelerated Approval work, and where these programs may apply, helps clarify what patients, families, and clinicians might expect as development moves forward. Where NRX-100 and NRX-101 Fit Clinically NRX-100 is being studied for rapid relief of acute suicidal ideation in depression, including bipolar depression. Ketamine’s rapid antidepressant effect is well documented, but its clinical use has been limited by temporary benefit and the need for monitored infusion. A proprietary, preservative-free …

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The Role of Therapy in Treating Depression

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Medically Reviewed by Mark Hrymoc, M.D., Chief Medical Officer, double-board certified in General & Addiction Psychiatry Depression is one of the most common and debilitating mental health conditions worldwide, affecting millions of people each year. While medication can play an important role in treatment, therapy is a cornerstone of effective depression care. Talk therapy provides a safe, structured environment for individuals to explore thoughts and emotions, develop coping strategies, and create long-term change. Research consistently shows that therapy not only alleviates symptoms but also reduces the risk of relapse, making it a vital tool in recovery. Understanding Depression and Its Impact Depression is more than just persistent sadness. It involves a range of symptoms such as fatigue, loss of interest in activities, sleep disturbances, appetite changes, difficulty concentrating, and feelings of worthlessness or hopelessness. Left untreated, it can interfere with work, relationships, and overall quality of life. According to the …

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How Seasonal Affective Disorder Impacts Mental Health

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Medically Reviewed by Mark Hrymoc, M.D., Chief Medical Officer, double-board certified in General & Addiction Psychiatry Seasonal Affective Disorder (SAD) is a type of depression that occurs at a specific time of year, most commonly during the fall and winter months when daylight hours are shorter. While occasional winter blues are common, SAD is a clinically recognized condition that can significantly impair daily functioning and overall mental health. Understanding its symptoms, underlying causes, and effective treatment options can help individuals manage the disorder and improve quality of life. Understanding Seasonal Affective Disorder SAD is categorized as a subtype of major depressive disorder or bipolar disorder, depending on the individual’s overall diagnosis. The most prevalent form is winter-pattern SAD, where symptoms begin in late autumn or early winter and resolve in spring or early summer. Less commonly, some individuals experience summer-pattern SAD, which emerges during the warmer months. The disorder is …

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The Role of Sleep in Managing Depression

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Medically Reviewed by Mark Hrymoc, M.D., Chief Medical Officer, double-board certified in General & Addiction Psychiatry Sleep and depression are closely linked, with each significantly influencing the other. Poor sleep can worsen depressive symptoms, while depression can interfere with the ability to fall asleep or stay asleep. Understanding how sleep and mood interact offers powerful insights for managing depression. When sleep is optimized, it can serve as a foundational element in emotional regulation and psychological recovery. Conversely, chronic sleep disturbances can undermine even the most effective treatment plans, making sleep hygiene a critical component of mental health care. How Depression Affects Sleep Patterns Depression often disrupts the body’s natural sleep-wake cycle, or circadian rhythm. People with depression may struggle with insomnia, waking frequently during the night, or experiencing early-morning awakenings that leave them feeling unrested. Others may experience hypersomnia, or excessive sleeping, without feeling refreshed. According to the National Sleep …

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